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As future direction, we present evidence showing that treatment using several antioxidants through respiratory delivery, both intranasal and intrapulmonary, may offer improved success over oral and dietary delivery

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ABC transporter A1 (ABCA1), a member of the ABC subfamily A, is involved in the reverse cholesterol transport pathway (RCT), which is crucial for regulating cellular cholesterol, phospholipid efflux and lipid homoeostasis [94]

Three distinct failure modes explain the historical record of oral peptide and protein failure: (1) Exposure infeasibility: A short elimination half-life prevents accumulation to a therapeutic body burden at low oral bioavailability, regardless of how sophisticated the formulation technology